Butterworth was born and raised in Lincoln, England on July 24, 1993 to an English father from Lancashire and an Italian American mother from Iowa. Her parents met in Nebraska where her mother was training to be a nurse and her father, in the Royal Air Force, was stationed at Offutt Air Force Base. She has dual citizenship.
From the age of 4 to 18, Butterworth attended Lincoln Minster School. She discovered acting through a school play and was Head Girl. She went on to graduate with a Bachelor of Arts in Acting from the Royal Academy of Dramatic Art (RADA) in 2014. Whilst training at RADA, Butterworth performed lead roles in The Daughter in Law and The Witch of Edmonton.
- DCI Banks as Holly (2015)
- WPC 56 as Lucy Hamilton (2015)
- Star Ocean: Anamnesis as Meracle (Voice) (2016)
- Say Your Prayers as Webcam Girl (2020)
- The North Water as Hester (2021)
- (A Very) Ham Fisted Stake Out as Erica (2017)